Educational content only — this is not medical advice. Nothing here is a recommendation to buy, obtain, or use Kisspeptin. Talk to a licensed clinician before making health decisions.
What it is
Kisspeptin is a family of peptides derived from the KISS1 gene. Kisspeptin-54 (metastin) and shorter fragments bind the KISS1R receptor on GnRH neurons to trigger release of gonadotropin-releasing hormone, which in turn drives LH and FSH secretion.
What the evidence shows
Human trials have shown that kisspeptin increases LH, FSH, and testosterone in men and can induce ovulation in women. It is under investigation for hypogonadotropic hypogonadism, infertility, and as a potential alternative to hCG trigger in IVF. No FDA-approved kisspeptin product exists as of 2026.
Risks & unknowns
Kisspeptin is generally well tolerated in clinical studies. Transient side effects include flushing, headache, and injection-site reactions. Because it drives the reproductive axis, overstimulation could theoretically cause ovarian hyperstimulation or hormone imbalances.
Legal / regulatory status
Kisspeptin is not FDA-approved. It is available only in clinical trials and research settings. It is prohibited by WADA under S2.